可吸收内固定板在颌面部骨折中临床应用

目的:应用可吸收内固定材料自生增强型聚丙交酯治疗颌面部骨折中的临床疗效观察。方法:对85例颌面部骨折患者,采用可吸收内固定材料做坚强内固定,6个月后复查伤口愈合情况,张口度恢复及咬合关系,摄X线片检查,判断骨折愈合情况。结果:全部病例术后X线检查骨折线对位良好,骨折愈合正常,咬合关系恢复良好,面部形态满意,未发现局部异物排斥反应及伤口感染。结论:可吸收内固定材料,由于生物相容性良好,具有一定强度,可降解吸收,在颌面部骨折手术治疗中是理想的内固定材料,值得推广应用。     

Long-Term Outcomes of Repeat Hepatic Resection in Patients with Recurrent Hepatocellular Carcinoma and Analysis of Recurrent Types and Their Prognosis: A Single-Center Experience in China

Background

Recurrent hepatocellular carcinoma (HCC) after curative resection usually originates from intrahepatic metastasis (IM) or multicentric occurrence (MO). The long-term outcomes of repeat hepatic resection in patients with different types of recurrence have not been evaluated in a large number of patients. The surgical indications for recurrent HCC remain controversial. The purpose of this study was to investigate long-term outcomes of repeat hepatic resection and clinicopathologic factors associated with different types of recurrent HCC, and to single out principle differentiating factors between IM and MO.

Methods

82 patients who underwent repeat hepatic resection for recurrent HCC were retrospectively studied. The recurrent type was evaluated by histopathologic analysis of primary and recurrent HCC. The recurrence and survival rates as well as clinicopathologic factors associated with different types of recurrence were analyzed.

Results

45 patients (54.9%) had confirmed with IM, and 37 patients (45.1%) had with MO. The recurrence rates in the MO patients after initial or repeat resection were significantly lower than those in the IM patients (p?p?Conclusions Repeat hepatic resection resulted in much higher survival rates in the MO patients than in the IM patients. Repeat hepatic resection could be recommended for those patients in whom the recurrent HCC occurs more than 18?months after initial resection.     

经腹腔腹腔镜下治疗肾盂旁囊肿28例

目的探讨经腹腔腹腔镜治疗肾盂旁囊肿的临床疗效。方法2004年至2011年,经腹腔腹腔镜行囊肿去顶减压术治疗肾盂旁囊肿28例,其中男15例,女13例,平均年龄45岁（34—67岁）,左侧16例,右侧12例。观察术后临床恢复及影像学改善情况。结果28例手术均顺利完成,无中转开腹。其中1例术中损伤肾实质,出血约100ml,缝合后血压平稳,无并发症发生;另1例将稍扩大的肾盂误认为囊肿,切开后一直有液体流出,遂留置DJ管。平均手术时间50min,平均术中出血量30ml,未见明显术中及术后并发症发生,术后平均住院时间5d,术后病理均为肾囊肿。术后随访6～24个月,临床症状消失,影像学检查均未见复发。结论腹腔镜下囊肿去顶减压视野清晰,损伤小,效果确切,是治疗。肾盂旁囊肿的理想方法。     

广东省DR专用检测项目比对结果分析

目的 通过对比对结果的分析,了解放射卫生技术服务机构在DR专项检测方面存在的问题,为提高检测能力提供依据。方法 采用整群抽样方法,以自愿参加本次比对的30家放射卫生技术服务机构为研究对象,采用基于四分位数稳健统计技术的z比分数对本次检测所提交的结果进行分析和评价。结果 在参加比对的30家机构所提交可分析的309项数据中,比对结果评价为满意的有267项,占比为86.4%;比对结果评价为可疑的有24项,占比为7.8%;比对结果离群的有18项,占比为5.8%。比对项目"STP"的结果最好,满意项占比为100%,比对项目"剂量测量"的离群结果占比最高,为20.0%,比对项目"极限空间分辨力"的可疑结果占比最高,为16.7%。结论 放射卫生技术服务机构技术水平有待提高,需加强日常质量控制管理,提升标准化操作意识,建设放射卫生检测数据平台,促进放射卫生检测行业健康发展。     

2013年某中医院ICU抗菌药物使用情况与细菌耐药性的相关性研究

目的：调查某中医院ICU抗菌药物的应用及细菌学情况,分析细菌耐药性,对抗菌药物使用情况进行评价。方法：利用Excel对ICU病房2003年1～12月抗菌药物的使用情况、细菌检查结果及其耐药性进行回顾性分析。结果：各类抗菌药物使用按DDDs排序,前三位分别为头孢菌素类（793.3）、碳青霉烯类（687.8）、四环素类（251.0）;按使用总量排序,前三位分别为美罗培南（1353.0g）、头孢哌酮舒巴坦（883.0g）、哌拉西林他唑巴坦（877.5g）。2013年ICU送检标本检出的146株细菌中,G-菌占82.2%,共120株,其中鲍曼不动杆菌64株;真菌占11.6%,共17株,其中白假丝酵母菌11株;G+菌占6.2%,共9株。结论：ICU抗菌药物使用特点符合检出细菌分布情况,细菌耐药性与抗菌药物的DDDs呈正相关性。     

超声乳化白内障吸除术中对向角膜切口矫正术前角膜散光的临床观察

目的 观察导航系统引导下超声乳化白内障吸除术中在角膜曲率最大子午线上行对向透明角膜切口矫正术前角膜散光的临床疗效.方法 队列研究.选择35例(40眼)术前角膜散光度均大于1.0 D白内障患者为实验组,在表面麻醉下于最大角膜曲率子午线上做2.8 mm对向透明角膜切口;另选27例(30眼)术前角膜散光度均大于1.0 D白内障患者为对照组,在表面麻醉下于最大角膜曲率子午线上做2.8 mm单个透明角膜切口.观察2组术前及术后3个月角膜散光度及平均角膜曲率的变化.根据Jaffe's矢量分析原理计算手术源性角膜散光,采用独立样本t检验与配对t检验进行数据分析.结果 对照组术前及术后3个月角膜散光度分别为(1.84±0.40)D和(1.49±0.36)D,差异有统计学意义(t=7.55,P＜0.05).实验组分别为(1.89±0.74)D和(0.71±0.60)D,差异有统计学意义(t=13.93,P＜0.05).术后3个月2组角膜散光度相比差异有统计学意义(t=-6.31,P＜0.05).2组手术源性散光分别为(0.38±0.18)D和(1.55±0.84)D.对照组术前及术后3个月平均角膜曲率分别为(44.18±1.31)D和(44.14±1.31)D,差异无统计学意义(t=1.21,P＞0.05).实验组分别为(44.33±1.51)D和(44.29±1.52)D,差异无统计学意义(t=0.73,P＞0.05).结论 超声乳化吸除术中行对向透明角膜切口是一种安全、有效的矫正角膜散光的方法.     

氧化苯胂对大鼠心室肌细胞L型Ca2+电流的影响

目的 :探讨氧化苯胂 （PAO） ,一种膜可通透的酪氨酸磷酸酶抑制剂 ,对大鼠心室肌细胞 L型 Ca2 +电流 （ICa,L）的影响。方法 :采用全细胞膜片钳技术记录大鼠心室肌细胞 ICa,L。结果 :1PAO对基础 ICa,L及β-肾上腺素受体激动剂异丙肾上腺素 （Iso）激发的 ICa,L有抑制作用 ;2 PAO对腺苷酸环化酶激动剂 forskolin激发的 ICa,L亦有抑制作用 ;3电极内液加入 1.5 mm ol/ L矾酸钠不能消除 PAO的作用 ;4PAO对 ICa,L的抑制作用可被二硫代苏糖醇反转。结论 :PAO抑制 ICa,L的作用与 c AMP- PKA-磷酸化途径和酪氨酸磷酸酶无关 ,可能与其使 L 型 Ca2 +通道蛋白上巯基氧化有关。     

大数据理解误区解读

大数据时代,面对众说纷纭的大数据热,本文详细地解读了大数据可以替代抽样调查、大数据不重视因果关系、大数据放松了数据质量、大数据可以完全取代数据科学家、大数据时代先收集数据后进行数据分析这5个误区。在此基础上,提出了在大数据发展的方兴未艾阶段如何更好地利用大数据的一些建议。     

Benzothiadiazole‐Containing Conjugated Polyelectrolytes for Biological Sensing and Imaging

This article summarizes the recent advances of benzothiadiazole (BT)‐containing conjugated polyelectrolytes (CPEs) for biological sensing and imaging. After a brief introduction of the molecular design principles, the application of linear BT‐containing CPEs as multicolor or light‐up probes for visual sensing of biomolecules is reviewed. Then, linear, grafted, and hyperbranched BT‐containing CPEs that can self‐assemble into nanoparticles or have intrinsic 3D structures for in vitro and in vivo imaging are summarized. The future outlook of BT‐containing CPEs for biomedical applications is also discussed at the end.

     

Association of human papillomavirus with Fanconi anemia promotes carcinogenesis in Fanconi anemia patients

Fanconi anemia (FA) is a rare recessive disorder associated with chromosomal fragility. FA patients are at very high risk of cancers, especially head and neck squamous cell carcinomas and squamous cell carcinomas caused by infection of human papillomaviruses (HPVs). By integrating into the host genome, HPV oncogenes E6 and E7 drive the genomic instability to promote DNA damage and gene mutations necessary for carcinogenesis in FA patients. Furthermore, E6 and E7 oncoproteins not only inhibit p53 and retinoblastoma but also impair the FANC/BRCA signaling pathway to prevent DNA damage repair and alter multiple signals including cell‐cycle checkpoints, telomere function, cell proliferation, and interference of the host immune system leading to cancer development in FA patients. In this review, we summarize recent advances in unraveling the molecular mechanisms of FA susceptibility to HPV‐induced cancers, which facilitate rational preventive and therapeutic strategies. Copyright © 2015 John Wiley & Sons, Ltd.